Liverpool duo Trent Alexander-Arnold and Jordan Henderson played in last year's final when they were beaten 3-1 by Real Madrid, before linking up with England for the World Cup in Russian Federation, but Southgate conceded an all-English final would present a new scenario.
Maddison impressed in his first season in the Premier League at Leicester City but is not be part of the senior set-up.
"He's finished the season really well with Southampton", he added. The level of the games are that level.
Southgate is still a massive fan of the tournament though, which he insists has gripped the nation and done wonders for his team's progress.
"This looks like being the same, there's a lot of uncertainty about who's going to be available until the last minute but we've got a strong squad with a lot of talent and we're looking forward to the matches". This competition has captured that.
He said: "That is a shame". But I think that is a shame for Test cricket as well. I think there are some things in my view that would be better shared for everybody, particularly kids. Those Champions League nights that we've just had might have had five-fold the numbers.
"But because of the money, broadcasting rights are done differently, and therefore other people miss out on that experience".
"So is it a preference for me that everybody can always see England matches?"
Like Kane, Spurs team-mates Danny Rose, Kieran Trippier, Eric Dier, Dele Alli and Harry Winks, as well as Reds trio Jordan Henderson, Joe Gomez and Trent Alexander-Arnold all face a quick turnaround to join the Three Lions in Portugal.
Unsurprisingly there are no uncapped players in Southgate's selection, while captain Harry Kane has been selected by Southgate despite an ankle ligament injury, while Harry Winks has also got the nod after groin surgery.
Southgate has confirmed that a reduced 23-man squad will be confirmed by Monday 27 May. "We just have to deal with it".