Murray announced his decision to exclusively concentrate on the gridiron Monday on Twitter.
"Football has been my love and passion my entire life", Murray added.
"I have started an extensive training program to further prepare myself for upcoming National Football League workouts and interviews".
Kyler Murray #1 of the Oklahoma Sooners reacts in the fourth quarter during the College Football Playoff Semifinal against the Alabama Crimson Tide at the Capital One Orange Bowl at Hard Rock Stadium on December 29, 2018 in Miami, Florida.
If selected in the first 32 picks, Murray would become the first player taken in the first round of both the MLB and NFL drafts, according to NFL research. He is officially dedicating himself to a full-time football career, bypassing the opportunity, at least for now, to play professional baseball.
Not even Denver Broncos general manager John Elway - the first overall pick in the 1983 NFL Draft and 52nd overall (second round) pick of the 1981 MLB Draft - can claim that. And that would have come for Murray only after who knows how many years in the minor leagues, playing for pennies in tiny towns and small stadiums while the A's delayed his major league debut in order to game his service time.
Murray made no mention of the A's or baseball in his statement.
Murray is not a carbon copy of Mayfield by any means, but like Mayfield, Murray has the "it" factor and understands how to operate an offense efficiently and has the wherewithal to go off-script when necessary and make big plays.
Oakland drafted Murray with the ninth overall pick last June.
Oklahoma quarterback Kyler Murray holds the Heisman Trophy after winning the award Saturday, Dec. 8, 2018, in NY. He will reportedly repay $1.29m (£1m) of the $1.5m (£1.17m) he received a year ago and forfeit the remaining $3.16m (£2.46m). In fact, he wrote: "I was raised to play QB".
There will always be kids who choose baseball, either because they love it the most or because their talents on the diamond outstrip their skills on the gridiron or basketball court.