The win, Liverpool's fifth in a row, propelled Jurgen Klopp's men one point ahead of Man City, who travel to Chelsea in the Saturday evening kick-off, as they maintained their superb unbeaten start to the 2018/19 top-flight campaign.
However, at the Vitality Stadium, he looked to be back to his very best.
The Reds made five changes to their starting XI following their 3-1 at Burnley at Turf Moor on Wednesday.
Then, in the second-half, he produced a moment of magic.
But before his finish, defender Steve Cook nastily caught Salah on the Achilles.
It was an act that Liverpool fans loved.
Salah's hat-trick - the first by a Liverpool player in an away game since Luis Suarez against Cardiff in 2014 - takes him to 10 Premier League goals for the season so far, putting him joint-top of the scoring charts with Arsenal's Pierre-Emerick Aubameyang.
Liverpool now face a must-win Champions League game against Napoli mid-week, which will make or break their hopes in the competition that they went all the way to the final in last season.