"Yes it is true if you said to me would you prefer all my worldwide players stay here and rest for two weeks without competition, I would say yes", he said.
Spurs head to Selhurst Park looking to make it four wins in a row in all competitions after Tuesday's dramatic 2-1 victory over PSV in Group B of the Champions League.
Pochettino once compared Kane to compatriot and former team-mate Gabriel Batistuta, and with Tottenham facing Crystal Palace on Saturday, he remains adamant it applies. That is why we were talking before about Dele Alli and Christian Eriksen and global duty. They have been unfortunate on a few occasions - you should see their expected goals, mate - and have picked up only eight points in 11 games.
"That is why we need to take care and send them really fresh".
'If Harry Kane is Italian and playing for the Italian side he will be a bit more protected because the Italian people are more protective of their players.
Kane's burning desire for goals was highlighted last season when he was ridiculed for his attempts to claim a goal at Stoke - one which was eventually awarded to him by the Premier League. It's hard to push [them to the top] but when they are there, they try to keep them up there.
"Of course now every time I decide to pick my starting XI I have a name I feel comfortable to play", he added. It's not only the pressure from the coaching staff, fans and club. That rumour you tell me and the opposite appeared [in the media] the other day. It is play, play, then move them there and play again.
"That is a very good thing that happens in teams that need to win".