The 76ers also snapped an eight-game losing streak at Bankers Life Fieldhouse that dated to April 2013.
"We finally put it together", said Australia's Simmons.
So just three nights after an inexplicable 25-point loss at Brooklyn, Embiid, Simmons and their teammates felt right at home in one of coach Brent Brown's favorite National Basketball Association arenas.
He scored 24 points in the first half on 10 of 16 shooting and finished with a season-high 36 points.
Domnatas Sabonis had 16 points and 11 rebounds but the Pacers didn't get much production from their bench and the 76ers exploited that.
IN closed the deficit to 29-23 after one quarter, used an 18-3 spurt in the second quarter to take a 41-36 lead and wound up tying the score 50-50 at halftime.
Embiid collected his league-high 11th double-double and Dario Saric scored a season-high 18 points by going 4-for-6 on three-pointers.
While it's still not ideal that the team shot less than 32 percent from 3-point range, a trend that has plagued the team all season, by sharing the ball and giving everyone a chance to score, the Philadelphia 76ers found a way to win a must-win game.
76ers: Had lost their previous five road games by an average of 15.2 points.
In other action, not even a season-high haul of 20 points from Australian guard Patty Mills was enough to prevent the San Antonio Spurs suffering a 95-88 loss to the Miami Heat. He also had seven assists, six rebounds and three blocks. Redick scored 10. Redick has scored in double figures in 21 consecutive games since March 26.
Pacers: Have lost consecutive home games for the first time this season. IN is now 5-2 against the Eastern Conference and 3-1 against Atlantic Division opponents.
Dennis Schroder scored a season-high 28 points as the Oklahoma City Thunder extended their winning run to six with a 95-86 away win against the Cleveland Cavaliers. IN was 12 of 17 from the free-throw line and 8 of 31 on 3-pointers. the only other player in double figures was Bojan Bogdanovic with 13.
Pacers: Hope to win their second straight at Miami on Friday after ending a six-game losing streak there last season.