During her performance, the 25-year-old almost fell during the song's second verse after she had climbed onto a white chair to sing a few lines. "Holding hands with my mama", she sang, through tears.
But she ran into some trouble dancing around the set, which was made to look like a wedding reception, stumbling when she stepped down from a chair.
Grande released "Thank U, Next" last week.
"One day I'll walk down the aisle".
Ariana Grande has shared an emotional message about dealing with a series of hardships following the Manchester Arena attack previous year, her failed engagement with ex Pete Davidson, and the death of her former boyfriend Mac Miller.
The moment gave her a slight case of the giggles as she went into the next verse, but she powered through.
But, just as the song says, Grande knows how to handle the pain.
Compared to breakup songs from other pop stars, like Taylor Swift, "Thank U, Next" is un-targeted, not revengeful and classy.
The single is Grande processing through past relationships, including her recently-ended engagement to "SNL" star Pete Davidson, thanking them for what they taught her and preparing her for whatever's next. She has reached the celebrity realm where she can fuck up and it makes us like her more. That was unbelievable! That was awesome.
It's been a rough few weeks for Ariana, but Billboard is recognising the incredible artist for her smashing year on the charts. "We love you, we support you". "Wrote songs about Ricky/Now I listen and laugh/Even nearly got married/And for Pete, I'm so thankful/Wish I could say "thank you" to Malcolm/'Cause he was an angel". "He is supposed to be here".
The Instagram Live footage was recorded after Grande filmed the Ellen segment on Tuesday, Nov. 6, and had vanished by the time video of the performance dropped on Wednesday, Nov. 7.