A fifth championship - secured at the last race in Mexico - moved Hamilton level with Juan Manuel Fangio in the all-time list, with only Schumacher on seven titles having won more.
Only Ferrari have enjoyed such a previous run, with six in succession between 1999 and 2004, and Sebastian Vettel and team mate Kimi Raikkonen are the only ones who can delay the seemingly inevitable.
Wolff insists the target for Mercedes remains to take both championships in 2018 and whilst the Constructors' Championship is still up in the air, everyone will be doing everything they can to clinch it this weekend in Brazil.
Mercedes are 55 points clear of the Italians, with 43 still to be won after Brazil.
Toto Wolff says Mercedes have "unfinished business" to attend to at the Brazilian Grand Prix as they strive to pull off a double.
"This is the moment to keep our feet on the ground, focus clearly on the objective and trust in our processes and people to deliver".
With his win in Mexico City, Hamilton has now a total of five titles which is only two behind Schumacher.
With no Brazilian driver in the race, Felipe Massa's departure at the end of a year ago ending an unbroken line extending over four decades, the carnival atmosphere may be slightly more muted.
Max Verstappen seems to be on a roll in the last part of this season, and Daniel Ricciardo looks like he is on the exact opposite of 'a roll.' Red Bull will be looking to finish the season strong and prepare for next year, and at this point, the Honey Badger will just be aiming to finish a race cleanly.
"I've had some great battles and overtakes there and I'm hoping for another exciting race".
"Mexico was a bittersweet weekend", explained Wolff.
All teams will approach Interlagos with some trepidation after Mercedes mechanics and others were targeted by armed robbers outside the circuit last time, with tighter security measures promised.