"We now assess this airstrike killed approximately 60 terrorists", US Africa Command which oversees US military operations on the continent said in a statement.
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Under President Donald Trump, the USA military has increased its involvement in the fight against al-Shabaab, which is affiliated with al Qaeda and the deadliest Islamic extremist group in sub-Saharan Africa. That is on pace to surpass last year's attacks against the group.
The U.S. Africa Command spokesman said the airstrike had no link to the anniversary.
Two officials tell The Associated Press that several missiles were fired on Friday by two unmanned United States drones.
Somalia on Sunday marked the first anniversary of al-Shabab's deadliest attack, a truck bombing in Mogadishu that killed well over 500 people.
It was the largest US airstrike since one on November 21, 2017, killed about 100 al-Shabab fighters.
The group, which is affiliated with al-Qaeda, has proved tenacious and regularly carries out deadly attacks against high-profile targets such as hotels and checkpoints in the capital and other cities.
They have been training and fighting alongside local troops in Somalia for more than a decade, and are now buttressed by invigorated airstrike authorities under the Trump administration.
Under President Trump, the U.S. military has increased its involvement in the fight against al-Shabaab, the deadliest Islamic extremist group in sub-Saharan Africa.
So far this year in Somalia, the United States has conducted 27 strikes, including by drone, mostly against small numbers of Al-Shabab fighters.
American warplanes struck the Al-Shabaab-controlled area of Haradere in Mudug province, which is located in north-central Somalia.
Ten days earlier, militants struck Somalia and U.S. forces in Mubarak, in central Somalia, killing one Somali soldier. "The enemy attacked us with 34 explosions, but only one hit one of our convoys", Koshin said.