Melania Trump's flight was cut short Wednesday morning when her plane suffered a "mechanical issue" that pumped smoke into the main cabin.
Reporters traveling with the first lady reported that 15 minutes after the plane took off smoke was spotted in the cabin and filled with a burning smell.
"Smell and smoke have since dissipated", NBC's Peter Alexander tweeted.
Passengers on board, including members of the press, were handed wet towels to help them breathe more easily while the plane returned to Joint Base Andrews in Maryland.
A crew member is quoted by U.S. media as saying a "malfunctioning comms unit that had overheated" was the cause of the issue, but the White House has not confirmed this.
She was on her way from Washington to Philadelphia when there was "a minor mechanical issue", according to her spokeswoman Stephanie Grisham.
"Everything is fine and everyone is safe", she said shortly.
Mrs Trump was due in Philadelphia to meet families affected by opioid abuse.
According to a Health and Human Services spokesperson, Trump will continue her journey once a new plane is ready.
Mrs Trump recently made her first major solo trip overseas to Ghana, Malawi, Kenya and Egypt.
The plane landed at the military base, and the first lady was seen getting off of the plane.