The Canadian singer's eldest son Noah (5) is in remission following treatment for hepatoblastoma.
In addition to Noah, the couple has a young son named Elias. The celebrity narcissism. I started to crumble.
Speaking about the tragedy of his son's diagnosis, he said: "My whole being has changed".
The crooner admitted he no longer "has the stomach" for fame and has "changed his perception on life" following his son's cancer diagnosis aged 3.
He speaks openly about the horror of facing his child's cancer diagnosis in a major new interview with the Mail on Saturday: "You just want to die". "I don't have the stomach for it any more", he admits.
He said: 'I decided I'll never read my name again in print, never read a review, and I never have. "I don't know if I can get through this conversation without crying, and I've never lost control of my emotions in public", he said. "I'm retiring. I've made the ideal record and now I can leave at the very top".
He continued: "It wasn't as straightforward as, "My son's recovered, I should make an album".
Buble has said he will retire from music following the release of his upcoming album.
The "Haven't Met You Yet" hitmaker has chose to step back from the spotlight following the release of his latest album "Love".
Michael Bublé is ready to leave the stage. "I'd told my manager I wanted to take a ten-year sabbatical, so I could hang out and be bad". So once when Luisana had to go back to Argentina I said to them, 'Come over to the house, let's drink, order pizza, play video games and jam'.
"More times than people could understand, some days we wished we didn't wake up".
His new album will be out in mid-November.
Buble - who has won four Grammys and sold 75million records - is also set to appear with James Corden on Carpool Karaoke in a special segment filmed for Stand Up To Cancer.