"Following the release of the Premier League fixtures for the 2018-19 season, we announced that, barring any significant issues with the final stages of stadium completion, our match against Liverpool on 15 September would be the first match in our new stadium", the statement read.
The club went on to explain: "Delays are common, certainly for builds of this size and complexity, however we are hugely frustrated that this has occurred with these systems at such a late stage".
"We simply can not compromise safety". The delays created by these difficulties mean that we can no longer hold the necessary Test Events on August 27 and September 1.
"We are acutely aware of the disappointment this may cause supporters and shall now look to ensure that we minimise any inconvenience".
"These will need to be rescheduled to take place ahead of any first official match at the new stadium in order to achieve the safety licence".
The new stadium was also due to host an National Football League game between Seattle Seahawks and Oakland Raiders on 14th October, with that fixture now being relocated to Wembley as well.
No timeline is in place, leaving an element of uncertainty over when the problems will be rectified and questions over when the club will begin life at the new 62,000-seater venue.
The report suggests that Spurs are exploring the option of postponing the Man City match.
"The option was in fact exercised at the end of previous year - and not in response to this issue - as a sensible back-up given the nature of construction and the possibility of exactly such an issue arising", the club added.
Tottenham chairman Daniel Levy said: "We know this will be disappointing for all our season tickets holders, premium members and our fans worldwide". The idea of fixtures being reversed, with the Etihad tie between the teams being moved to October, has also been ruled out.