The match will also be new Arsenal manager Unai Emery's first in English football's top flight.
The 2018-19 fixtures, announced on Thursday morning, handed Pep Guardiola's record-breaking team an Emirates Stadium opener on the weekend of August 11/12.
Perhaps the most eagerly anticipated game next season will not be the Manchester derby, but the first clash between City and Liverpool at Anfield on October 6.
North London rivals Arsenal face a tough first two games without Arsene Wenger.
Liverpool's start appears more challenging.
During the opening six fixtures, City are due to play all three promoted teams, handing Guardiola's men the flawless opportunity to make another strong start to the season.
Spurs are due to move back to their rebuilt home on the site of White Hart Lane for the new season, with Fulham their first scheduled visitors on the weekend of August 18/19.
Championship-winning Wolves have a home opener against Everton, before trips to Leicester and West Ham sandwich the visit of Manchester City to Molineux.
The other first day fixtures see Southampton host Burnley and Watford take on Brighton at Vicarage Road.