Kami Rita, a veteran Sherpa guide, also claimed a new record for Mount Everest summits by making it to the peak for the 22nd time with a group of climbers.
Most hopefuls are escorted by a Nepali guide, meaning about 700 climbers will tread the same path to the top of the 8,850-metre (29,035-foot) peak in the coming weeks.
A guide for more than two decades, he broke the previous record of 21 summits that he shared with two other Sherpas.
According to mountaineering officials, Sherpa reached the summit at 8:30 am on Wednesday.
A 44-year-old woman, Lhakpa Sherpa, who lives in Connecticut, United States, climbed for the ninth time on Wednesday, breaking her own record of the most summits by a woman, her Nepali hiking company said.
He made his first ascent of the Everest in 1994 when he was 24 years old.
A year ago seven people lost their lives on the world's highest peak, while 449 summited from the Nepal side and at least another 120 made it to the top from the north side in Tibet. Phurba Tashi, 47, retired from high-altitude climbing in 2013 but still works at Everest's Base Camp helping organize expeditions.
Rajeev Shrestha of the Seven Summit Adventure agency in Kathmandu said he received a message from the base camp about the successful climb. She lives most of the year in the USA state of CT and has a son and two daughters.
He completed the seven climbs in 177 days - nine days quicker than the previous record - after reaching the top of Everest on Monday (May 14).
Xia Boyu is not the first double-amputee to reach Everest's peak, but he is the oldest.
Hundreds of climbers are on Everest attempting to reach the summit during the narrow window of good weather in May.
Nepal has issued 346 permits to mountaineers for this year's spring climbing season, which runs from mid-April to the end of May.