The World Champions are joining the Maori All Blacks, USA Eagles, Italy and Ireland at Chicago's National Football League stadium Soldier Field in November as part of a massive afternoon of rugby action.
The All Blacks lost to Ireland in Chicago in 2016.
Although the IRFU have yet to confirm the kick-off times for their remaining fixtures inNovember, pending broadcast agreements being reached, it is expected that Ireland will return from Chicago to host Argentina, the All Blacks and the United States of America at the Aviva Stadium in that order.
On November 3, the US Eagles will also take on the New Zealand Maori, while the US Eagles women's team will face the New Zealand women's team.
The iconic National Football League stadium will play host to three captivating worldwide rugby matches over the course of one day, featuring Ireland's clash with Six Nations rivals Italy and the USA Men's and Women's Eagles taking on the Maori All Blacks and Women's Rugby World Cup Champions the Black Ferns respectively.
IRFU Director of Commercial and Marketing Padraig Power said: "Irish Rugby is delighted to be returning to Chicago". We are looking forward to an exciting match against Italy who are a well-coached and unsafe team, ' said IRFU director of commercial and marketing, Padraig Power.
The clash between the two Six Nations opponents will be the first game of Ireland's November series, which will also feature matches against Argentina and New Zealand in Dublin.