City's Champions League conqueror moved ever closer to sealing its place in the competition next season as Liverpool cruised past Bournemouth with Salah again taking centrestage.
Huddersfield rose to 14th thanks to an injury-time goal by Tom Ince while Jordan Ayew returned from a three-match ban to earn Swansea a draw against Everton.
However, in just eight minutes a 2-0 lead over Chelsea evaporated into a 3-2 defeat.
However, City continued their pressing game and soon they got a result to show for it as Spurs goalkeeper, Lloris tripped Raheem Sterling just at the edge of the box in the 24th minute. Harry Kane played the ball through for the Danish midfielder, whose shot was deflected back off his own leg and into the back of the net, sparking thousands of tweets saying Kane will claim the goal from folks who think they're really amusing.
Despite going two down earlier in the game, Mauricio Pochettino's men were not going to give up the fight that early as they were also in the search to reduce the deficit before the end of the first half.
Having scored their first goal of the game, the confidence of the home team grew as ball possession had risen to 42% for the hosts while the away team still maintain dominance but by a slim margin.
Kane at least returned the favour as Eriksen scored in the 42nd minute.
After the miss, both teams quickly introduced new players to their sides - as Erik Lamela made way for Heung-Min Son in a tactical substitution, while Nicolas Otamendi replaced Leroy Sane to beef up the defence line. "You could see the difference in the attitude to players compared to last week", said the Portuguese coach.
Lloris compounded Spurs' problems moments later when Sterling was played in and taken out by Lloris.
"Spurs didn't have a game for a week". Dele Alli nearly got the second goal but he was challenged by a Manchester City defender as the host continued to probe further for their second goal.
Manchester City travels to Wembley at the back of three straight defeats and will be hoping to avoid a fourth when they meet Tottenham who are unbeaten since December.