At 92 years old, Bush has been suffering for some time and has been in and out of the hospital multiple times in the last year while battling with Chronic Obstructive Pulmonary Disease, or COPD, and congestive heart failure.
The former first lady, the statement said, "will instead focus on comfort care".
Barbara Bush, the wife of former U.S. President George H.W. Bush, is in "failing health" and has made a decision to no longer seek medical treatment, the office of the ex-president said in a statement from Houston on Sunday.
'She is surrounded by a family she adores, and appreciates the many kind messages and especially the prayers she is receiving'. Her husband, the 41st USA president, is 93 years old.
The 92-year-old wife of President George H.W. Bush is now being care for at her Houston, Texas home.
Bush served as First Lady from 1989 through 1993, and previously as Second Lady when her husband George H.W. Bush was Vice President in the Reagan administration from 1981 until 1989.
Bush is the only living wife of one former President and the mother of another former President.