Skripal moved to Britain in a spy swap in 2010 and settled in Salisbury, and his daughter Yulia was visiting from Russian Federation when they were poisoned, possibly on his front door.
The national security adviser said that President Putin "was closely involved in the Russian chemical weapons..."
"The programme subsequently included investigation of ways of delivering nerve agents, including by application to door handles".
Police investigating the Salisbury poisoning said the highest concentration of the Novichok nerve agent had been found on Sergei Skripal's front door.
Britain said Thursday that an worldwide chemical weapons monitoring organization's report strongly bolsters the case for Kremlin guilt in last month's poisoning of onetime spy Sergei Skripal, 66, and his daughter, Yulia, 33.
According to the embassy's maycommentary, "the case against Russian Federation is based on three elements: the identification of the chemical agent, far-fetched speculations and conclusions regarding the "operational experience" and "motive", as well as unverifiable 'intelligence'".
Yulia Skripal, who was poisoned in Britain last month along with her father, a former Russian spy, has said she did not wish to take up the offer of services from the Russian embassy in London, according to a statement issued on her behalf by the Metropolitan police. So far, we doubt it much.
She is in the care of "trained officers" who are taking her through the investigative process. "It is unlikely that Novichoks could be made and deployed by non-state actors (eg a criminal or terrorist group), especially at the level of purity confirmed by OPCW". "The use of weapons of this kind can never be justified, and must be ended", Johnson said.
Skripal had moved to Britain in 2010 as part of a spy exchange after being imprisoned in Russian Federation for selling secrets to British intelligence while he was working for the GRU.
He also said Russian intelligence cyber specialists had targeted Skripal's daughter Yulia's email accounts in 2013.
"There are over 100 British journalists here, why are none of you calling to meet Miss Skripal - not a single person?"
Russia, which denies it was behind the attack in Salisbury, called the allegations an "anti-Russian campaign".
Russia's ambassador to the United Kingdom, Alexander Yakovenko, dismissed the charges Friday as unfounded and untrue.
"I find myself in a totally different life than the ordinary one I left just over a month ago, and I am seeking to come to terms with my prospects, whilst also recovering from this attack on me", she said.
Zakharova added there were doubts that a recent statement by Yulia Skripal was authentic.