Speaking to a crowd who attended a pop concert marking his election victory, Mr Putin hailed those who voted for him as a "big national team", adding that "we are bound for success".
With 31 percent of the votes counted, mostly in eastern part of the country, Vladimir Putin leads with 73 percent of the vote, well above the simple majority needed to avoid a run-off.
By 5pm Moscow time, authorities said turnout had hit almost 52%.
"Who am I voting for?"
He said that the nation needs unity to move forward and urged the audience to "think about the future of our great motherland". They remain hospitalized in serious condition.
The vote was tainted by widespread reports of ballot-box stuffing and forced voting, but the complaints will likely do little to undermine Putin.
The Russian leader's popularity remains high despite his suppression of dissent and reproach from the West over Russia's increasingly aggressive stance in world affairs and alleged interference in the 2016 USA election. Constitutionally barred from serving more than two consecutive terms, he did not run in 2008, the same year presidential terms were extended from four years to six years.
People cast their ballots at a polling station in Yelizovo, Russian Far East, Russia, on March.
The 65-year-old former KGB agent appeared confident after casting his vote in Moscow. In addition, US federal prosecutors are investigating whether Russian-linked groups interfered during the 2016 presidential election.
Election monitors are reporting irregularities at voting stations across Russian Federation in a presidential election whose only open question is how many people cast ballots.
That shouldn't come as a surprise, since Putin didn't face a real oppositional challenge.
Putin was first elected to the Kremlin in 2000, and again four years later. The election will be held on March 18, 2018.
Eight candidates are running for the highest office in the Russian Federation. Voters also faced billboards celebrating Russian greatness - a major theme of Putin's leadership.
Across the country in the city of Yekaterinburg, a doctor also said she was being coerced to vote.