Winfrey's speech on the importance of tackling gender and racial inequality and the #MeToo movement catapulted her into the U.S. political debate this week as confidantes raised the possibility that she might declare as a Democratic candidate in the 2020 presidential campaign.
While supporting the idea of Oprah's candidacy, Brad Anderson, former USA president Barack Obama's 2020 Iowa campaign director, said, "Look, it's ridiculous - and I get that. I'd much rather go for someone like Oprah Winfrey than a career politician".
One wag even etched it into the world's reference tool, Wikipedia, editing in an entry that read, "Oprah Winfrey basically announced her run for the presidency on January 8, 2018, at the 75th Golden Globe Awards".
"And here's why. The media and the left in this country, well, they now seem to think Oprah is the one person that can help them fulfill their ultimate goal-to destroy Donald Trump and defeat President Trump", he added.
Trump spoke Tuesday at the White House as he met with lawmakers on immigration. "She would absolutely do it". "The idea of a reality show star running against a talk show host is troublingly dystopian", he tweeted this week. However Mr Trump has dismissed her chances.
"No, I like Oprah, I don't think she's gonna run".
I think she's been a plausible candidate at least since 2008 when she stumped for Barack Obama in the south, in the primary and possibly even longer than that. She had read it to me for time, but it was the type of thing where she knew she had a message to deliver.
"She writes her column every month in the magazine". Spielberg, in London to promote his new movie The Post, said: "If she declares, I will back her". She's a very good writer.
So I think for Americans who are looking for that, she would be an excellent representative of it and for Americans who are looking for something different, she isn't all that different.
"I said, "Lady, it is going to cost me some money but you are going to shoot the lights out".
'Whether she is leading us to the candidate we need or whether she herself is a candidate, she sets the bar pretty high on campaign talk, ' Streep said.