The travel alert includes Minot, Devils Lake, Grand Forks and surrounding areas.
The approval by the Health Department's advisory group is another important step in the process as the department develops a medical marijuana program, which voters approved in November 2016.
North Dakota's Health Department has established eight regions for medical marijuana dispensaries.
State law allows medical marijuana for 17 medical conditions and terminal illnesses. The drug isn't expected to be available to patients until late this year.
A travel alert issued for the remainder of the state has also been lifted. The Health Department has been working to create the program since Gov. Doug Burgum last April approved regulations crafted by lawmakers.
The application period closed Monday for proposals for a system to monitor the medical marijuana program, including helping register dispensaries and patient card holders.