In a statement, Google said it had been "trying to reach agreement with Amazon to give consumers access to each other's products and services" but, "given the lack of reciprocity", had chose to no longer support YouTube on Echo Show or FireTV.
The feud is the latest in Silicon Valley to put customers in the crossfire of major competitors. Amazon's suite of voice-controlled devices has outsold Google's so far, according to a study by research firm eMarketer from earlier this year.
In a statement, Google said, "Amazon doesn't carry Google products like Chromecast and Google Home, doesn't make (its) Prime Video available for Google Cast users, and last month stopped selling some of (our sister company) Nest's latest products".
Google certainly took its time, but has clearly had enough and has made the decision to pull YouTube - the largest public video platform in the world - from being accessed on Amazon's hardware devices such as Echo Show and Fire TV.
"We hope we can reach an agreement to resolve these issues soon", says Google.
The Google-owned video service is cutting access to the Amazon device on January 1, a Google spokeswoman said Monday.
A tit-for-tat move, as Amazon refuses to sell many of Google's products that compete with its own products on its retail website. Not so with Google. Amazon later reintroduced YouTube to the device, but the voice commands it added violated the use terms and on Tuesday Google again removed the service. Google is miffed by the fact that it is losing ad revenue from Fire TV which was the best selling streaming device in USA and India.