"By failing to adequately limit population growth, reassess the role of an economy rooted in growth, reduce greenhouse gases, incentivize renewable energy, protect habitat, restore ecosystems, curb pollution, halt defaunation, and constrain invasive alien species, humanity is not taking the urgent steps needed to safeguard our imperiled biosphere", they write.
"Humanity is now being given a second notice, as illustrated by these alarming trends", said the letter.
The letter is thought to have the most support ever for a scientific article, with a total of 15,372 signatures from researchers across a range of scientific disciples.
Writing in the online global journal BioScience, the scientists led by top USA ecologist Professor William Ripple, from Oregon State University, said: "Humanity is now being given a second notice ..."
They said environmental impacts were likely to inflict "substantial and irreversible harm" on the Earth.
"Scientists are in the business of analyzing data and looking at the long-term consequences", Ripple said in a release.
They said progress made in some areas, including reducing ozone-depleting chemicals and increasing renewable energy generation, had been far outweighed by the damage.
Prof. Ripple said: "Those who signed this second warning aren't just raising a false alarm".
There has also been a rapid decline in the number of children women are having as education levels increase and the rate of deforestation in some regions has also slowed. They are acknowledging the obvious signs that we are heading down an unsustainable path.
These include a 26 per cent reduction in the amount of fresh water available per capita, a drop in the harvest of wild-caught fish, despite an increase in fishing effort and a 75 per cent increase in the number of ocean dead zones.
"We are hoping that our paper will ignite a widespread public debate about the global environment and climate".
Taking a numerical look at how some of the threats have grown since 1992, the scientists note that there's been a 26.1 percent loss in fresh water available per capita; a 75.3 percent increase in the number of "dead zones"; a 62.1 percent increase in Carbon dioxide emissions per year; and 35.5 percent rise in the human population.
But if there is the will, mankind can move the Earth's systems toward sustainability.
"Humanity has failed to make sufficient progress in generally solving these foreseen environmental challenges, and alarmingly, majority are getting far worse", they write.
The authors include a cautionary note: "Soon it will be too late to shift course away from our failing trajectory, and time is running out".