Jose Mourinho has lost just two of his 39 previous Premier League games against newly-promoted sides (W33 D4) - against Crystal Palace in 2013-14 and Bournemouth in 2015-16. Indeed, the striker struggled to make his mark against Liverpool, and hardly had a sniff against Benfica despite United dominating possession for long spells.
Forward Collin Quaner has similarly been ruled out of the clash with United, although is expected to be back for the subsequent trip to Liverpool seven days later after recently returning to training following a calf problem picked up during the 1-1 draw with Leicester last month.
Matic has proven to be the most influential player in United's midfield and he will be looking to continue his good work against Huddersfield Town as well.
Manchester United have been on impressive form during the entire season. If he needs surgery, it will be 12 weeks, if not, it will be eight weeks. They are, however, only three points clear of the relegation zone as things stand.
Huddersfield had a terrific start start to the season winning their first two games in the Premier League.
But with Mourinho at the helm of a side that can frighten every defence in the league, the Terriers could find themselves in awe of their opponents, struggling to contain the flair and pace that the United frontline possesses. "Laurent did well but you need competition and now Steve is back we have that". The 23-year-old scored twice in his first four Premier League appearances, but has not featured since the defeat at West Ham on September 11.
Aaron Mooy will return to the Huddersfield XI after starting on the bench against Swansea last weekend due to his involvement for Australia during the global break.
Marcus Rashford is fit despite limping off during United's Champions League win over Benfica in midweek. Though, the Old Trafford outfit will be without Eric Bailly, Phil Jones, Paul Pogba and others, they will still be expected to come out on top as the same betting companytags them as favourites at (1.35).
Midfielders Michael Carrick and Marouane Fellaini remain out through injuries, meaning United have the same group of players available for the trip to Huddersfield as they took to the Portuguese capital.
Man Utd could become the first team in top-flight history to keep eight clean sheets in their first nine matches of a season.
While Huddersfield have had a free week to prepare for this match, United were in Champions League action away to Benfica on Wednesday night. Against Huddersfield though, Lukaku will be confident of scoring a goal or two.