The team of Aaliyah Brown, Allyson Felix, Morolake Akinosun, and Tori Bowie did not always have it easy in the final, though Bowie in the anchor leg held off a British charge to take another gold medal for the U.S. team in a time of 41.82 seconds.
The Sand Hill native became the first double gold medalist at the world championships, adding to the 100 meter crown she won last week.
Allyson Felix, part of that winning team in Daegu, ran the second leg before passing on to Morolake Akinosun who handed the baton to Bowie, the 100m world champion.
For Great Britain, the quartet of Asha Philip, Desiree Henry, Dina Asher-Smith and Daryll Neita came home in 42.12 seconds as the United States claimed gold in a world-leading 41.82secs. However, Bowie held firm and produced a great final leg to take gold, with Britain in second and Sashalee Forbes bringing home the Bronze for Jamaica.